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Discover GRI’s commitment to high ethical and legal standards in scientific research. Learn about our rigorous guidelines for human subjects, bio-hazardous agents, and international compliance. Legal & Ethical Guidelines GRI will conform with all existing Laws of Sri Lanka regarding the performance of scientific research. Where such Laws do not exist, we will seek guidance from regional and international Laws. GRI will act as a responsible scientific entity, and will maintain high ethical and legal standards at every stage of the research project. We will require the following from all external researchers: All projects involving human subjects or human specimens will be evaluated by a GRI institutional review board (IRB). Human subject research requires the approval of the GRI IRB as well as the IRB of the investigators' home institution. A written guarantee of the source, the collection methodology of the tested material and the end use of the data is required. For samples with restricted access such as protected or endangered species, the external researcher has to provide copies of permits or permission from relevant authorities. GRI retains the right to verify the legal and ethical status of any tested material, in consultation with relevant authorities or experts. GRI retains the right to terminate the research project at any time if it is discovered that that the tested material was obtained illegally or unethically. GRI will not be held responsible for any observations and conclusions made from such research, or for any subsequent action taken by any person in response to such observations and conclusions (except when the research is performed in collaboration with a senior scientist at GRI). Projects involving work with bio-hazardous agents will be reviewed and only undertaken if the specimens do not pose a significant risk to people working on the project or others. Only international shipments that are compliant with local and foreign import/export regulations will be allowed.

Meet Samudi Mohotti, Genetech’s Senior Scientist leading parentage testing, with over 3,000 DNA reports for Sri Lanka’s judiciary. Samudi Mohotti Senior Scientist Samudi Mohotti commenced her professional career at Genetech as a Scientific Officer at the division of parentage testing in 2004. In subsequent years, she was promoted to the post of Senior Scientist and currently oversees the entire process of parentage testing. She is one of the most experienced scientists in the field of DNA typing and has contributed to submit over 3,000 DNA test reports for civil and criminal cases to the Sri Lankan Judiciary. She took part in the development of an allele frequency databases of autosomal STR markers for Sri Lankans ethnicities and co-authored a journal paper in a high-impact journal, Forensic Science International: Genetics. In addition to DNA typing, she is involved in many research projects conducted by Genetech on contract basis to meet the requests from both state and private institutes. She is also a key member of the team which maintains the ISO 15189 quality management system of our laboratory. Samudi obtained her BSc degree in Biological Sciences from the University of Colombo, Sri Lanka and her Master’s degree in Applied Microbiology from the University of Kelaniya, Sri Lanka.

Discover Genetech’s journal publications on genetic research and advancements in Sri Lanka, shaping the future of molecular diagnostics and biodiversity. Sathkumara, H. D., Merritt, A. J., Corea, E. M., Krishnananthasivam, S., Natesan, M., Inglis, T. J. J. & De Silva, A. D. (2018) Clinical, Bacteriologic, and Geographic Stratification of Melioidosis Emerges from the Sri Lankan National Surveillance Program. Am J Trop Med Hyg . 98(2), 607-615. Available from: doi: 10.4269/ajtmh.17-0441 Grifoni, A., Weiskopf, D., Arlehamn, C. S. L., Angelo, M., Leary, S., Sidney, J., Frazier, A., Phillips, E., Mallal, S., Mack, S. J., Tippalagama, R., Goonewardana, S., Premawansa, S., Premawansa, G., Wijewickrama, A., De Silva, A. D. & Sette, A. (2018) Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 714 adults from Colombo, Sri Lanka. Hum Immunol . 79(2), 87-88. Available from: doi: 10.1016/j.humimm.2017.12.007 Patil, V. S., Madrigal, A., Schmiedel, B. J., Clarke, J., O'Rourke, P., de Silva, A. D., Harris, E., Peters, B., Seumois, G., Weiskopf, D., Sette, A. & Vijayanand, P. (2018) Precursors of human CD4+ cytotoxic T lymphocytes identified by single-cell transcriptome analysis. Sci Immunol . 3(19). Available from: doi: 10.1126/sciimmunol.aan8664 Nanayakkara, K. K., Rodrigo, U. G., Perera, K. L. N. & Nanayakkara, C. D. (2017) Pre-natal diagnosis of thalassaemia in Sri Lanka: A ten year review. J Obstet Gynaecol . 37(7), 861-863. Available from: doi: 10.1080/01443615.2017.1306841 de Silva, W.S.I., Perera, M.M.N., Perera, K.L.N.S., Wickramasuriya, & A.M., Jayasekera G.A.U. (2017) In silico Analysis of osr40c1 Promoter Sequence Isolated from Indica Variety Pokkali. Rice Science, Vol. 24 (4): 228-234 Available from: doi: 10.1016/j.rsci.2016.11.002 . Gunasekara, J.M.A., Jayasekera, G.A.U, Perera, K.L.N.S. & Wickramasuriya, A.M, (2017) Development of a Sri Lankan rice variety Bg 94-1 harbouring cry2A gene of Bacillus thuringiensis resistant to rice leaffolder [Cnaphalocrocis medinalis (Guenée)]. Journal of the National Science Foundation of Sri Lanka, 45(2): 143–157. Available from: doi: 10.4038/jnsfsr.v45i2.8180 Goonawardhana, N.D.S., Jayasekara, G.S.K.W., Elanahai, V., Udagama, P.V., & Fernandopulle N.D. (2017) Population genetic data for ten miniSTR loci in the Sri Lankan population. International Journal of Legal Medicine. 131(4):969-970. Available from: doi: 10.1007/s00414-016-1512-3 Tian, Y., Babor, M., Lane, J., Schulten, V., Patil, V. S., Seumois, G., Rosales, S. L., Fu, Z., Picarda, G., Burel, J., Zapardiel-Gonzalo, J., Tennekoon, R. N., De Silva, A. D., Premawansa, S., Premawansa, G., Wijewickrama, A., Greenbaum, J. A., Vijayanand, P., Weiskopf, D., Sette, A. & Peters, B. (2017) Unique phenotypes and clonal expansions of human CD4 effector memory T cells re-expressing CD45RA. Nat Commun. 8(1), 1473. Available from: doi: 10.1038/s41467-017-01728-5 Grifoni, A., Angelo, M. A., Lopez, B., O'Rourke, P. H., Sidney, J., Cerpas, C., Balmaseda, A., Silveira. C. G. T., Maestri, A., Costa, P. R., Durbin, A. P., Diehl, S. A., Phillips, E., Mallal, S., De Silva, A. D., Nchinda, G., Nkenfou, C., Collins, M. H., de Silva, A. M., Lim, M. Q., Macary, P. A., Tatullo, F., Solomon, T., Satchidanandam, V., Desai, A., Ravi, V., Coloma, J., Turtle, L., Rivino, L., Kallas, E. G., Peters, B., Harris, E., Sette, A. & Weiskopf, D. (2017) Global Assessment of Dengue Virus-Specific CD4+ T Cell Responses in Dengue-Endemic Areas. Front Immunol. Available from: doi: 10.3389/fimmu.2017.01309 Grifoni, A., Pham, J., Sidney, J., O'Rourke, P. H., Paul, S., Peters, B., Martini, S. R., de Silva, A. D., Ricciardi, M. J., Magnani, D. M., Silveira, C. G. T., Maestri, A., Costa, P. R., de-Oliveira-Pinto, L. M., de Azeredo, E. L., Damasco, P. V., Phillips, E., Mallal, S., de Silva, A. M., Collins, M., Durbin, A., Diehl, S. A., Cerpas, C., Balmaseda, A., Kuan, G., Coloma, J., Harris, E., Crowe Jr, J. E., Stone, M., Norris, P. J., Busch, M., Vivanco-Cid, H., Cox, J., Graham, B. S., Ledgerwood, J. E., Turtle, L., Solomon, T., Kallas, E. G., Watkins, D. I., Weiskopf, D. & Sette, A. (2017) Prior Dengue virus exposure shapes T cell immunity to Zika virus in humans. J Virol. 91(24). Available from: doi: 10.1128/JVI.01469-17 Uehara, A., Tissera, H. A., Bodinayake, C. K., Amarasinghe, A., Nagahawatte, A., Tillekeratne, L. G., Cui, J., Reller, M. E., Palihawadana, P., Gunasena, S., De Silva, A. D., Wilder-Smith, A., Gubler, D. J., Woods, C. W. & Sessions, O. M. (2017) Analysis of Dengue Serotype 4 in Sri Lanka during the 2012-2013 Dengue Epidemic. Am J Trop Med Hyg. 97(1), 130-136. Available from: doi: 10.4269/ajtmh.16-0540 Krishnananthasivam, S., Jayathilaka, N., Sathkumara, H. D., Corea, E., Natesan, M. & De Silva, A. D. (2017) Host gene expression analysis in Sri Lankan melioidosis patients. PLoSNegl Trop Dis . 11(6). Available from: doi: 10.1371/journal.pntd.0005643 Krishnananthasivam, S., Sathkumara, H. D., Corea, E., Natesan, M. & De Silva, A. D. (2017) Gene Expression Profile of Human Cytokines in Response to Burkholderia pseudomallei Infection. mSphere . 2(2). Available from: doi: 10.1128/mSphere.00121-17 Grifoni, A., Angelo, M., Sidney, J., Paul, S., Peters, B., de Silva, A. D., Phillips, E., Mallal, S., Diehl, S. A., Botten, J., Boyson, J., Kirkpatrick, B. D., Whitehead, S. S., Durbin, A. P., Sette, A. & Weiskopf, D. (2017) Patterns of Cellular Immunity Associated with Experimental Infection with rDEN2Δ30 (Tonga/74) Support Its Suitability as a Human Dengue Virus Challenge Strain. J Virol . 91(8). Available from: doi: 10.1128/JVI.02133-16 Natesan, M., Corea, E., Krishnananthasivam, S., Sathkumara, H. D., Dankmeyer, J. L., Dyas, B. K., Amemiya, K., De Silva, A. D. & Ulrich, R. G. (2017) Calprotectin as a Biomarker for Melioidosis Disease Progression and Management. J Clin Microbiol. 55(4), 1205-1210. Available from: doi: 10.1128/JCM.02284-16 Angelo, M. A., Grifoni, A., O'Rourke, P. H., Sidney, J., Paul, S., Peters, B., De Silva, A. D., Phillips, E., Mallal, S., Diehl, S. A., Kirkpatrick, B. D., Whitehead, S. S., Durbin, A. P., Sette, A. & Weiskopf, D. (2016) Human CD4+ T cell responses to an attenuated tetravalent dengue vaccine parallel those induced by natural infection, in magnitude, HLA restriction and antigen specificity. J Virol . 91(5). Available from: doi: 10.1128/JVI.02147-16 Bodinayake, C. K., Tillekeratne, L. G., Nagahawatte, A., Devasiri, V., Kodikara Arachichi, W., Strouse, J. J., Sessions, O. M., Kurukulasooriya, R., Uehara, A., Howe, S., Ong, X. M., Tan, S., Chow, A., Tummalapalli, P., De Silva, A. D., Østbye, T., Woods, C. W., Gubler, D. J. & Reller, M. E. (2016) Emergence of Epidemic Dengue-1 Virus in the Southern Province of Sri Lanka. PLoS Negl Trop Dis. 10(10). Available from: doi: 10.1371/journal.pntd.0004995 Kamaral, L. C. J., Dassanayaka, P. N., Perera, K. L. N. S. & Perera, S. A. C. N. (2016) SSR markers reveal the population structure of Sri Lankan yellow dwarf coconuts (Cocos nucifera L.). Tree Genetics & Genomes 12, 116. Available from: doi: 10.1007/s11295-016-1076-x Kirupananthan, R., Kamaral, L. C. J., Galhena, G. H., Perera, K. L. N. S. & Magamage, M. P. S. (2016) Address the public health and food security concerns of babesiosis through molecular detection of Babesia bovis in suspected carrier cattle of selected localities in Sri Lanka. Procedia Food Science 6: 213-219. Available from: doi: 10.1016/j.profoo.2016.02.053 Weiskopf, D., Angelo, M. A., Grifoni, A., O'Rourke, P. H., Sidney, J., Paul, S., De Silva, A. D., Phillips, E., Mallal, S., Premawansa, S., Premawansa, G., Wijewickrama, A., Peters, B. & Sette, A. (2016) HLA-DRB1 Alleles Are Associated With Different Magnitudes of Dengue Virus-Specific CD4+ T-Cell Responses. J Infect Dis. 214(7), 1117-1124. Available from: doi: 10.1093/infdis/jiw309 de Alwis, R., Bangs, D. J., Angelo, M. A., Cerpas, C., Fernando, A., Sidney, J., Peters, B., Gresh, L., Balmaseda, A., de Silva, A. D., Harris, E., Sette, A. & Weiskopf, D. (2016) Immunodominant Dengue Virus-Specific CD8+ T Cell Responses Are Associated with a Memory PD-1+ Phenotype. J Virol. 90(9), 4771-4779. Available from: doi: 10.1128/JVI.02892-15 Olsen, A., Chen, Y., Ji, Q., Zhu, G., De Silva, A. D., Vilchèze, C., Weisbrod, T., Li, W., Xu, J., Larsen, M., Zhang, J., Porcelli, S. A., Jacobs Jr, W. R. & Chan, J. (2016) Targeting Mycobacterium tuberculosis Tumor Necrosis Factor Alpha-Downregulating Genes for the Development of Antituberculous Vaccines. MBio. 7(3). Available from: doi: 10.1128/mBio.01023-15 Tissera, H., Amarasinghe, A., Gunasena, S., De Silva, A. D., Yee, L. W., Sessions, O., Muthukuda, C., Palihawadana, P., Lohr, W., Byass, P., Gubler, D. J. & Wilder-Smith, A. (2016) Laboratory-Enhanced Dengue Sentinel Surveillance in Colombo District, Sri Lanka: 2012-2014. PLoS Negl Trop Dis. 10(2). Available from: doi: 10.1371/journal.pntd.0004477 Weiskopf, D., Angelo, M., Zapardiel, J., Seumois, G., De Silva, A., De Silva, A. D., Vijay, P., Peters, B. & Sette, A. (2016) DENV-specific CD4 T-cells dominantly recognize capsid-derived epitopes and display a cytotoxic phenotype. J Immunol . 196 (1). Available from: https://www.jimmunol.org/content/196/1_Supplement/147.13/tab-article-info Padumadasa, C., Perera, K. L. N. & Sankalpani, E. M. N. (2016) DNA intercalation and cleavage studies of plumbagin and phenanthroline-based Cu(II) complex, [Cu(PLN)(PHEN)]NO3. Int J Chem Stud. 4(4), 87-90. Available from: https://www.chemijournal.com/archives/?year=2016&vol=4&issue=4&ArticleId=282&si=false Fernando, A. N., Malavige, G. N., Perera, K. L. N., Premawansa, S., Ogg, G. S. & De Silva, A. D. (2015) Polymorphisms of Transporter Associated with Antigen Presentation, Tumor Necrosis Factor-α and Interleukin-10 and their Implications for Protection and Susceptibility to Severe Forms of Dengue Fever in Patients in Sri Lanka. Journal of Global Infectious Diseases. 7(4): 157–164. Available from: doi: 10.4103/0974-777X.170501 Weiskopf, D., Cerpas, C., Angelo, M. A., Bangs, D. J., Sidney, J., Paul, S., Peters, B., Sanches, F. P., Silvera, C. G., Costa, P. R., Kallas, E. G., Gresh, L., de Silva, A. D., Balmaseda, A., Harris, E. & Sette, A. (2015) The Human CD8+ T-Cell Responses Against the 4 Dengue Virus Serotypes Are Associated With Distinct Patterns of Protein Targets. J Infect Dis . 212(11), 1743-1751. Available from: doi: 10.1093/infdis/jiv289 Page 2 of 3 Journal Publications 1 2 3

Access Genetech Research Institute’s journal publications on genetic polymorphisms, kinship analysis, dengue vectors, and more, contributing to scientific advancements and innovation. Weiskopf, D., Bangs, D. J., Sidney, J., Kolla, R. V., De Silva, A. D., de Silva, A. M., Crotty, S., Peters, B. & Sette, A. (2015) Dengue virus infection elicits highly polarized CX3CR1+ cytotoxic CD4+ T cells associated with protective immunity. Proc Natl Acad Sci USA. 112(31), E4256-E4263. Available from: doi: 10.1073/pnas.1505956112 Krishnananthasivam, S., Fernando, A. N., Tippalagama, R., Tennekoon, R., De Man, J., Seneviratne, D., Premawansa, S., Premawansa, G. & De Silva, A. D. (2015) Evaluation of a commercial rapid test kit for detection of acute dengue infection. Southeast Asian Journal of Tropical Medicine and Public Health. 46(4), 602-610. Available from: https://www.researchgate.net/publication/280836227_Evaluation_of_a_commercial_rapid_test_kit_for_detection_of_acute_dengue_infection Sathkumara, H. D., De Silva, N. R., Handunnetti, S. & De Silva, A. D. (2015) Genetics of common variable immunodeficiency: role of transmembrane activator and calcium modulator and cyclophilin ligand interactor. Int J Immunogenet. 42(4), 239-253. Available from: doi: 10.1111/iji.12217 Tillekeratne, L., Bodinayake, C., Nagahawatte, A., Vidanagama, D., Devasiri, V., Kodikara Arachchi, W., Kurukulasooriya, R., De Silva, A. D., Østybe, T., Reller, M. E. & Woods, C. W. (2015) An Under-Recognized Influenza Epidemic Identified by Rapid Influenza Testing, Southern Sri Lanka, 2013. American journal of tropical medicine and hygiene . 92(5), 1023-1029. Available from: doi: 10.4269/ajtmh.14-0708 Jayawardana, W. A. D., Jayasekera, G. A. U., Wijesundara, R. L. C., Dissanayake, D. M. N., Sooriyapathirana, S. D. S. S., Webadde, C. K., Perera, K. L. N. S., Gunapala, K. R. D. & Hettige, P. (2014). “Evaluation of DNA markers Linked to Blast Resistance Genes Pikh, Pitp and Pita for parental selection in Sri Lankan Rice Breeding”. Tropical Agricultural Research. 26(1), 82-95. Available from: doi: 10.4038/tar.v26i1.8074 Kamaral, L. C. J., Perera, S. A. C. N., Perera, K. L. N. S. & Dasanayake, P. N. (2014). Genetic Diversity of the Sri Lanka Yellow Dwarf Coconut Form as Revealed by Microsatellite Markers. Tropical Agriculture Research. Vol. 26 (1): 131-139. Available from: doi: 10.4038/tar.v26i1.8078 Weiskopf, D., Angelo, M. A., Bangs, D. J., Sidney, J., Paul, S., Peters, B., De Silva, A. D., Lindow, J. C., Diehl, S. A., Whitehead, S., Durbin, A., Kirkpatrick, B. & Sette, A. (2014) The Human CD8+ T Cell Responses Induced by a Live Attenuated Tetravalent Dengue Vaccine Are Directed against Highly Conserved Epitopes. J Virol. 89(1), 120-8. Available from: doi: 10.1128/JVI.02129-14 Corbett, K. S., Katzelnick, L., Tissera, H., Amerasinghe, A., de Silva, A. D. & de Silva A. M. (2014) Preexisting Neutralising Antibody Responses Distinguish Clinically Inapparent and Apparent Dengue Virus Infections in a Sri Lankan Pediatric Cohort. J Infect Dis. 211(4), 590-599. Available from: doi: 10.1093/infdis/jiu481 Tissera, H., Amarasinghe, A., De Silva, A. D., Kariyawasam, P., Corbett, K. S., Katzelnick, L., Tam, C., Letson, G. W., Margolis, H. S. & de Silva, A. M. (2014) Burden of Dengue Infection and Disease in a Pediatric Cohort in Urban Sri Lanka. American Journal of Tropical Medicine & Hygiene . 91(1), 132-137. Available from: doi: 10.4269/ajtmh.13-0540 Ocwieja, K. E., Fernando, A. N., Sherrill-Mix, S., Sundararaman, S. A., Tennekoon, R. N., Tippalagama, R., Krishnananthasivam, S., Premawansa, G., Premawansa, S. & De Silva, A. D. (2014) Phylogeography and Molecular Epidemiology of an epidemic strain of Dengue Virus Type 1 in Sri Lanka. American Journal of Tropical Medicine & Hygiene . 91(2), 225-234. Available from: doi: 10.4269/ajtmh.13-0523 Calis, J. J. A., Maybeno, M., Greenbaum, J. A., Weiskopf, D., De Silva, A. D., Sette, A., Kesmir, C. & Peters, B. (2013) Properties of MHC Class I Presented Peptides That Enhance Immunogenicity. PLoSComputBiol 9(10): e1003266. Available from: doi: 10.1371/journal.pcbi.1003266 Tissera, H. A., Amarasinghe, A., de Silva, A. M., Tam, C. C., De Silva, A. D., Letson, G. W. & Margolis, H. S. (2013) Surveillance of dengue in a community cohort in Metropolitan Colombo, Sri Lanka: part I methods and study population. Dengue Bulletin. 37, 141-159. Available from: https://www.researchgate.net/profile/Anun_Chaikoolvatana/publication/266919317_GIS_Based_Surveillance_to_Support_DHF_Control_in_Thailand_from_2009_to_2011/links/543f70430cf21c84f23cd2d0.pdf#page=149 Tissera, H. A., Amarasinghe, A., de Silva, A. M., De Man, J. & De Silva, A. D. (2013) A comparison of an in-house IgM and IgG assay with a commercial Panbio kit, in a paediatric cohort in Colombo, Sri Lanka. Dengue Bulletin . 37, 101-106. Available from: http://apps.who.int/iris/bitstream/handle/10665/204944/B5077.pdf;jsessionid=020BC61ACDC2C27C6A59AA5E97637C71?sequence=1 Tam, C. C., Tissera, H., de Silva, A. M., De Silva, A. D., Margolis, H. S. & Amarasinge, A. (2013) Estimates of dengue force of infection in children in Colombo, Sri Lanka. PLoSNegl Trop Dis. 7(6):e2259. Available from: doi: 10.1371/journal.pntd.0002259 Weiskopf, D., Angelo, M. A., de Azeredoa, E. L., Sidney, J., Greenbaum, J. A., Fernando, A. N., Broadwater, A., Kolla, R. V., De Silva, A. D., de Silva, A. M., Mattia, K. A., Doranz, B. J., Grey, H. M., Shresta, S., Peters, B. & Sette, A. (2013) Comprehensive analysis of dengue virus-specific responses supports an HLA-linked protective role for CD8+ T cells. Proc Natl Acad Sci USA . Available from: doi: 10.1073/pnas.1305227110 Rathnayake, N. R. M. K. N. D., Bentota, A. P., Dissanayake, D. M. N., Perera, K. L. N. S., Sooriyapathirana, S. D. S. S. & Jayasekera, G. A. U. (2012) DNA Markers RM 464A and RM 219 Haplotypes are Effective in Selecting Sub-1 locus for the Introgression of Submergence Tolerance into New Rice Varieties. Ceylon Journal of Science (Bio. Sci.) 41 (2): 125-136. Available from: doi: 10.4038/cjsbs.v41i2.5382 Tissera, H. A., Ooi, E. E., Gubler, D. J., Tan, Y., Logendra, B., Wahala, M. P. B. W., de Silva, A. M., Abeysinghe, M. R. N., Palihawadana, P., Gunasena, S., Tam, C. C., Amarasinghe, A., Letson, G. W., Margolis, H. S. & De Silva, A. D. (2011) New dengue virus type 1 genotype in Colombo, Sri Lanka. Emerging Infectious Diseases. 17(11), 2053-2055. Available from: doi: 10.3201/eid1711.101893 Weiskopf, D., Yauch, L. E., Angelo, M. A., John, D. V., Greenbaum, J. A., Sidney, J., Kolla, R. V., De Silva, A. D., de Silva, A. M., Grey, H., Peters, B., Shresta, S. & Sette, A. (2011) Insights into HLA-Restricted T Cell Responses in a Novel Mouse Model of Dengue Virus Infection Point toward New Implications for Vaccine Design. J. Immunol. Available from: doi: 10.4049/jimmunol.1101970 Malavige, G. N., Rostron, T., Rohanachandra, L. T., Jayaratne, S. D., Fernando, N., De Silva, A. D., Liyanage, M. & Ogg, G. (2011) HLA Class I and Class II Associations in Dengue Viral Infections in a Sri Lankan Population. PLoS ONE 6(6): e20581. Available from: doi: 10.1371/journal.pone.0020581 Seneviratne, D. B., Amuduwage, S., Weerasingam, S. & Fernandopulle, N. D. (2010) Hepatitis C virus in healthy blood donors in Sri Lanka. Asian Journal of Transfusion Science. Available from: doi: 10.4103/0973-6247.75976 Tissera, H. A., De Silva, A. D., Abeysinghe, M. R. N., De Silva, A. M., Palihawadana, P., Gunasena, S., Tam, C. C., Gamage, T. M., De Silva, T., Rajapaksa, L. C., Amarasinghe, A., Letson, G. W. & Margolis, H. S. (2010) Dengue Surveillance in Colombo, Sri Lanka: Baseline seroprevalence among children. Procedures in Vaccinology 2: 2010) 109-112. Available from: doi: 10.1016/j.provac.2010.03.020 Illeperuma, R. J., Markalanda, D., Fernanadopulle, N. D. & Ratnasooriya, W. D. (2010). Genetic variation at 11 autosomal STR loci in the aboriginal people, the Veddahs of Sri Lanka. Forensic Science international: Genetics 4 (2010) 142. Available from: doi: 10.1016/j.fsigen.2009.05.007 Illeperuma, R. J., Markalanda, D., Mountain, J. L., Ratnasooriaya, W. D., Fernandopullae, N. D. & Bamshad, M. J. (2010) Haplotype data for 12 Y-chromosome STR loci of Sri Lankans. Forensic Science international: Genetics 4 (2010) e119e120. Available from: doi: 10.1016/j.fsigen.2009.10.003 Kanakaratne, N., Wahala, W. M. P. B., Messer, W. B., Tissera, H. A., Shahani, A., Abeysinghe, N., Thevanesam, V., de Silva, A. M. & Gunasekera, M. (2009) Severe dengue epidemics in Sri Lanka: 2003-2006. Journal of CDC-Emerging Infectious Diseases. 15 (2). Available from: doi: 10.3201/eid1502.080926 Illeperuma, R. J., Mohotti, S. N. K., De Silva, M. T., Fernandopulle, N. D. & Ratnasooriya, W. D. (2008) Genetic Profile of 11 Autosomal STR Loci Among the Four Major Ethnic Groups in Sri Lanka, Forensic Science International: Genetics 3 (3): 105-106. Available from: doi: 10.1016/j.fsigen.2008.10.002 Senevirathna, D., Ranaweera, D., Abeysekera, D., Kanakarathana, N., De Silva, D., Abeysundara, S., Samaraweera, P., Jayasinghe, S. & Fernandopulle, N. (2008) Genotypes of hepatitis C virus (HCV) in liver disease patients in Sri Lanka. Southeast Asian J Trop Med Public Health. 2008 Nov;39(6):1054-6. Available from: https://pubmed.ncbi.nlm.nih.gov/19062694/ Page 3 of 3 Journal Publications 1 2 3

Explore DNA structure, genetic engineering, and practical lab techniques in this comprehensive 60-hour course. Learn about PCR, DNA fingerprinting, and more. Certificate Course in Gene Technology (60 hours) Who is this course for? This course is ideal for students who have completed their G.C.E. Advanced Level or Ordinary Level examinations and are planning to pursue higher studies in biology, biotechnology, or medicine. It offers the perfect foundation to confidently step into a university-level molecular biology programme, blending theoretical knowledge with extensive practical exposure. What you will learn 30 Hours of Multimedia-Assisted Lectures Introduction to gene technology, molecular biology and Recombinant DNA technology Proteins and proteomics DNA fingerprinting, GMOs & bioinformatics PCR, DNA sequencing & future biotech innovations 30 Hours of Hands-On Laboratory Practicals Micropipette handling & lab safety Reagent preparation & DNA extraction Spectrophotometric DNA quantification (Nanodrop) Plasmid DNA isolation & bacterial transformation Restriction Enzyme digestion & gel electrophoresis PCR (standard, multiplex) & RT-PCR Microscopy of mitotic cell division Polyacrylamide and Capillary Electrophoresis Course Highlights Learn from experienced scientists Get trained in modern molecular biology techniques Ideal for students applying to local & foreign universities Receive a certificate upon successful completion Course Dates, Duration and Fees Dates: Monday, 16th February 2026 - Friday, 27th February 2026 (excluding weekends and holidays) Time: 9.00 am - 4.30 pm Duration: 60 hours (10 days) Course Fee: LKR 64,500 per person View FAQs Contact us If you are interested in doing this course at Genetech, please submit the Inquiry Form below or email us at info@genetechsrilanka.com to receive further details. View Inquiry Form

Explore Genetech’s DNA typing quality control, upholding international standards with expert staff, cutting-edge methods, and stringent error checks. Quality Control DNA typing is a highly specialised procedure which requires knowledge and skill. Furthermore, for DNA typing evidence to be acceptable in a Court of Law, it has to meet certain quality standards, which have been well documented and followed by forensic DNA laboratories worldwide. Accordingly in 2010, we became the first DNA typing laboratory in Sri Lanka to achieve ISO 15189:2007 (now 15189:2012) accreditation from Sri Lanka Accreditation Board (SLAB). We at Genetech are proud to announce that every step of our DNA typing process meets these international standards. At Genetech, our quality standards cover all aspects of DNA typing, including qualified and experienced personnel, the latest equipment, and the best of chemicals and reagents. The entire process is performed to generate error-free results which can be verified by any laboratory in the world. Personnel: Genetech has the most experienced and qualified personnel in the field of DNA typing in Sri Lanka. They have pioneered DNA typing in this country, and have laid the foundation for the application of this technology in Sri Lanka. Equipment: We are a fully equipped organisation which has the ability to perform automated fragment analysis in the exact manner required by the standards. Our equipment are regularly calibrated to ensure error-free functioning. Laboratory management: All aspects of laboratory management and documentation are performed to meet the ISO 15189 standards. Aspects of confidentiality, security and independence have been diligently maintained. Technical quality: The type of DNA testing done by us is the latest, most accepted method known as Polymerase Chain Reaction (PCR) based analysis of Short Tandem Repeats (STRs). This method is presently accepted by the forensic community as the method of choice because of its sensitivity, accuracy, rapidity and cost effectiveness. The type of genetic test: STR loci (genetic locations) which are tested by us are those that are well-studied and regularly used by the forensic community. These include loci found on autosomes, and X and Y chromosomes. The STR loci tested by us are among the most accepted, internationally. These STR loci have also been tested for their suitability to be used for the Sri Lankan population, and they have been proven to be statistically suitable. There is also an established Sri Lankan population database for these loci which enables such DNA evidence to be presented to a Court of Law. In addition to STR testing, we also conduct mitochondrial DNA analysis as required, to assist tracing of maternal lineages. Error minimisation: In order to minimise the possibility of error, we will maintain standards of validation and verification. The analysis of casework samples will be done alongside internationally used standard human DNA, and the results of the casework analysis will be subject to comparison with these DNA standards. Negative controls will be run at every step of the analysis procedure in order to ensure that no cross-contamination of DNA has occurred. Reporting: Once DNA typing results are generated, they are stored in both a graphic format as well as in a numerical format. An individual's DNA profile can be submitted to a Court of Law in both formats. Our scientists can provide statistical interpretation of the results and express the accuracy of the test by statistical means, using data generated from the Sri Lankan human population databases. In order to be valid in a Court of Law, DNA evidence must be supported by statistical data. This data is obtained only by establishing a population database for the population group that is being tested. Therefore, only Sri Lankan population data can be used for such analyses.

Explore Genetech’s technical services in Molecular Biology and Biochemistry. We provide precise sample analysis for researchers using established protocols. Learn about our analytical expertise today. Technical Services Genetech Research Institute offers technical services in Molecular Biology and Biochemistry-related ventures. We will provide analytical services as required by an external researcher: GRI will analyse samples provided by the external researcher using established protocols at GRI or detailed protocols provided by the external investigator. Samples will be analysed by the technical staff of Genetech and results will be reported to the external researcher. The external researcher will be charged a fee based on the number of samples and type of analysis. GRI will not be held responsible for any observations and conclusions made from this research.

Explore custom oligonucleotide and gene synthesis services with various modifications, purification options, free cloning, and sequencing for 100% accuracy. Oligonucleotide and Gene synthesis We offer primer synthesis services covering different concentration scales from 0.025 to 1µmole. Different purification options using techniques such as desalt, MOPC, HPLC and PAGE are available as per requirement of the customer. We also offer primer modifications such as fluorescent labelling, non-fluorescent modifications, dark quenchers and internal modifications. Oligonucleotide/Primer synthesis Gene synthesis We offer customised gene synthesis services in a plasmid DNA state with a free cloning service, as well as free DNA sequencing to confirm the sequence of the gene. Our customised gene synthesis service offers to generate genes based on the sequence requirement of the customer. With our free cloning service, the synthesised gene is made available in a plasmid DNA state. Our free sequencing service guarantees 100% sequence accuracy. Contact us

Discover Genetech’s journal publications on genetic research and advancements in Sri Lanka, shaping the future of molecular diagnostics and biodiversity. Perera, N., Galhena, G. & Ranawaka, G. (2021) X-chromosomal STR based genetic polymorphisms and demographic history of Sri Lankan ethnicities and their relationship with global populations. Scientific Reports 11:12748. Available from: doi: 10.1038/s41598-021-92314-9 Perera, N., Galhena, G. & Ranawaka, G. (2021) Development of a 16 X-STR multiplex PCR system for kinship analysis and its applicability for the Sinhalese population in Sri Lanka. International Journal of Legal Medicine. 135:161–166. Available from: doi: 10.1007/s00414-020-02450-6 Nirmani, M. D., Perera, N. S. & Galhena, G. H. (2021) Population genetic dynamics of dengue vectors Aedes aegypti and Aedes albopictus in Sri Lanka: Baseline study for designing Wolbachia control method. International Journal of Tropical Insect Science. 41:1809–1821. Available from: doi: 10.1007/s42690-020-00395-2 Jayasinghearachchi, H. S., Francis, V. R., Sathkumara, H. D., Krishnananthasivam, S., Masakorala, J., Muthugama, T., De Silva, A. D. & Corea, E. M. (2021) Nonclonal Burkholderia pseudomallei Population in Melioidosis Case Cluster, Sri Lanka. Emerging Infectious Diseases. 27 (11). Available from: doi: 10.3201/eid2711.210219 Nirmani, M. D., Perera, N. S. & Galhena, G. H. (2020) The scope of Rp EPIC markers in population genetic studies: a preliminary study with dengue vectors. Journal of the National Science Foundation of Sri Lanka, 48(3): 275-288. Available from: doi: 10.4038/jnsfsr.v48i3.9311 Dharmarathne, H. A. K. M., Weerasena, O. V. D. S. J., Perera, K. L. N. & Galhena, G. (2020) Genetic characterization of Aedes aegypti (Diptera: Culicidae) in Sri Lanka based on sequence polymorphism of COI gene. Journal of Vector Borne Diseases 57 (2):151–158. Available from: doi: 10.4103/0972-9062.310871 Powell, L. A., Miller, A., Fox, J. M., Kose, N., Klose, T., Kim, A. S., Bombardi, R., Tennekoon, R. N., de Silva, A. D., Carnahan, R. H., Diamond, M. S., Rossmann, M. G., Kuhn, R. J. & Crowe, J. E. Jr. (2020) Human mAbs Broadly Protect against Arthritogenic Alphaviruses by Recognizing Conserved Elements of the Mxra8 Receptor-Binding Site. Cell Host & Microbe. 28(5), 699-711.e7. Available from: doi: 10.1016/j.chom.2020.07.008 Mutucumarana, C. P., Bodinayake, C. K., Nagahawatte, A., Devasiri, V., Kurukulasooriya, R., Anuradha, T., De Silva, A. D., Janko, M. M., Østbye, T., Gubler, D. J., Woods, C. W., Reller, M. E., Tillekeratne, L. G. & Lantos, P. M. (2020) Geospatial analysis of dengue emergence in rural areas in the Southern Province of Sri Lanka. Trans R Soc Trop Med Hyg. 114(6), 408-414. Available from: doi: 10.1093/trstmh/trz123 Grifoni, A., Voic, H., Dhanda, S. K., Kidd, C. K., Brien, J. D., Buus, S., Stryhn, A., Durbin, A. P., Whitehead, S., Diehl, S. A., De Silva, A. D., Balmaseda, A., Harris, E., Weiskopf, D. & Sette, A. (2020) T Cell Responses Induced by Attenuated Flavivirus Vaccination Are Specific and Show Limited Cross-Reactivity with Other Flavivirus Species. Journal of Virology. 94(10) Available from: doi: 10.1128/JVI.00089-20 Mapalagamage, M., Handunnetti, S. M., Wickremasinghe, A. R., Premawansa, G., Thillainathan, S., Fernando, T., Kanapathippillai, K., De Silva, A. D. & Premawansa, S. (2020) High levels of Serum Angiopoietin 2/1 Ratio at the Critical Stage of Dengue Hemorrhagic Fever in Patients and Association with Clinical and Biochemical Parameters. J Clin Microbiol. 58(4). Available from: doi: 10.1128/JCM.00436-19 Nirmani M. D., Perera, K. L. N. & Galhena, G. H. (2019) Use of ovitrap surveillance to assess dengue outbreak risks in selected dengue endemic areas in Sri Lanka. Sri Lankan Journal of Biology 4(2): 32-46. Available from: doi: 10.4038/sljb.v4i2.39 Tian, Y., Seumois, G., De-Oliveira-Pinto, L. M., Mateus, J., Herrera-de la Mata, S., Kim, C., Hinz, D., Goonawardhana, N. D. S., de Silva, A. D., Premawansa, S., Premawansa, G., Wijewickrama, A., Balmaseda, A., Grifoni, A., Vijayanand, P., Harris, E., Peters, B., Sette, A. & Weiskopf, D. (2019) Molecular Signatures of Dengue Virus-Specific IL-10/IFN-g Co-producing CD4 T cells and their Association with Dengue Disease. Cell Rep. 29(13), 4482-4495.e4. Available from: doi: 10.1016/j.celrep.2019.11.098 Burel, J. G., Pomaznoy, M., Lindestam Arlehamn, C. S., Weiskopf, D., da Silva Antunes, R., Jung, Y., Babor, M., Schulten, V., Seumois, G., Greenbaum, J. A., Premawansa, S., Premawansa, G., Wijewickrama, A., Vidanagama, D., Gunasena, B., Tippalagama, R., de Silva, A. D., Gilman, R. H., Saito, M., Taplitz, R., Ley, K., Vijayanand, P., Sette, A. & Peters, B. (2019) Circulating T cell-monocyte complexes are markers of immune perturbations. Elife. Available from: doi: 10.7554/eLife.46045.001 Grifoni, A., Moore, E., Voic, H., Sidney, J., Phillips, E., Jadi, R., Mallal, S., De Silva, A. D., De Silva, A. M., Peters, B., Weiscopf, D. & Sette, A. (2019) Characterization of Magnitude and Antigen Specificity of HLA-DP, DQ, and DRB3/4/5 Restricted DENV-Specific CD4+ T Cell Responses. Front Immunol. Available from: doi: 10.3389/fimmu2019.01568 Jayasinghearachchi, H. S., Corea, E. M., Krishnananthsivam, S., Sathkumara, H. D., Francis, V. R., Abeysekere, T. R. & De Silva, A. D. (2019) Whole-Genome Sequences of Eight Clinical Isolates of Burkholderia Pseudomallei from Melioidosis Patients in Eastern Sri Lanka. Microbial Resour Announc. 8(33). Available from: doi: 10.1128/MRA.00645-19 Kose, N., Fox, J. M., Sapparapu, G., Bombardi, R., Tennekoon, R. N., De Silva, A. D., Elbashir, S. M., Theisen, M. A., Humphris-Narayanan, E., Ciaramella, G., Himansu, S., Diamond, M. S. & Crowe Jr, J. E. (2019) A lipid-encapsulated mRNA encoding a potently neutralizing human monoclonal antibody protects against chikungunya infection. Science Immunology. 4(35). Available from: doi: 10.1126/sciimmunol.aaw6647 Tian, Y., Babor, M., Lane, J., Seumois, G., Liang, S., Goonawardhana, N. D. S., De Silva, A. D., Phillips, E. J., Mallal, S. A., da Silva Antunes, R., Grifoni, A., Vijayanand, P., Weiskopf, D., Peters, B. & Sette, A. (2019) Dengue-specific CD8+ T cell subsets display specialized transcriptomic and TCR profiles. The journal of clinical investigation. 129(4), 1727-1741. Available from: doi: 10.1172/JCI123726 Vimonish, R., Galhena, G. H., Perera, K. L. N. & Magamage, M. P. S. (2018) PCR based approach for detection of bovine babesiosis in suspected carrier cattle and vector ticks in Sri Lanka. Journal of Agricultural Sciences – Sri Lanka, 13(1):55–65. Available from: doi: 10.4038/jas.v13i1.8300 Raut, R., Corbett, K. S., Tennekoon, R. N., Premawansa, S., Wijewickrama, A., Premawansa, G., Mieczkowski, P., Rückert, C., Ebel, G. D., De Silva, A. D. & de Silva, A. M. (2018) Dengue type 1 viruses circulating in humans are highly infectious and poorly neutralized by human antibodies. Proc Natl Acad Sci USA . 116(1), 227-232. Available from: doi: 10.1073/pnas.1812055115 Tillekeratne, L. G., Bodinayake, C. K., Simmons, R., Nagahawatte, A., Devasiri, V., Kodikara Arachchi, W., Nicholson, B. P., Park, L. P., Vanderburg, S., Kurukulasooriya, R., De Silva, A. D., Østybe, T., Reller, M. E. & Woods, C. W. (2018) Respiratory Viral Infection: An Underappreciated Cause of Acute Febrile Illness Admissions in Southern Sri Lanka. Am J Trop Med Hyg . 100 (3), 672-680. Available from: doi: 10.4269/ajtmh.18-0699 Grifoni, A., Costa-Ramos, P., Pham, J., Tian, Y., Rosales, S. L., Seumois, G., Sidney, J., De Silva, A. D., Premkumar, L., Collins, M. H., Stone, M., Norris, P. J., Romero, C. M. E., Durbin, A., Ricciardi, M. J., Ledgerwood, J. E., de Silva, A. M., Busch, M., Peters, B., Vijayanand, P., Harris, E., Falconar, A. K., Kallas, E., Weiskopf, D. & Sette, A. (2018) Cutting Edge: Transcriptional Profiling Reveals Multifunctional and Cytotoxic Antiviral Responses of Zika Virus-Specific CD8+ T Cells. J Immunol . 201 (12), 3487-3491. Available from: doi: 10.4049/jimmunol.1801090 Mapalagamage, M., Handunnetti, S., Premawansa, G., Thillainathan, S., Fernando, T., Kanapathippillai, K., Wickremasinghe, R., De Silva, A. D. & Premawansa, S. (2018) Is Total Serum Nitrite and Nitrate (NOx) Level in Dengue Patients a Potential Prognostic Marker of Dengue Hemorrhagic Fever. Dis Markers . Available from: doi: 10.1155/2018/5328681 Fernando, S. J. A., Faiz, N. M., Handunnetti, S. M., De Silva, A. D., Dasanayake, W. M. D. K., Wickramasinghe, G. D., Karunatilake, R. M. C. H. & de Silva, N. R. (2018) Preliminary study on chronic granulomatous disease in Sri Lanka. Allergy Asthma Clin Immunol. 14, 37. Available from: doi: 10.1186/s13223-018-0264-7 Corea, E. M., de Silva, A. D. & Thevanesam, V. (2018) Melioidosis in Sri Lanka. Trop Med Infect Dis. 3(1). Available from: doi: 10.3390/tropicalmed3010022 Bodinayake, C. K., Tillekeratne, L. G., Nagahawatte, A., Devasiri, V., Kodikara Arachchi, W., Strouse, J. J., Sessions, O. M., Kurukulasooriya, R., Uehara, A., Howe, S., Ong, X. M., Tan, S., Chow, A., Tummalapalli, P., De Silva, A. D., Østbye, T., Woods, C. W., Gubler, D. J. & Reller, M. E. (2018) Evaluation of the WHO 2009 classification for diagnosis of acute dengue in a large cohort of adults and children in Sri Lanka during a dengue-1 epidemic. PLoS Negl Trop Dis . 12(2). Available from: doi: 10.1371/journal.pntd.0006258 Montoya, M., Collins, M., Dejnirattisai, W., Katzelnick, L. C., Puerta-Guardo, H., Jadi, R., Schildhauer, S., Supasa, P., Vasanawathana, S., Malasit, P., Mongkolsapaya, J., de Silva, A. D., Tissera, H., Balmaseda, A., Screaton, G., de Silva, A. M. & Harris, E. (2018) Longitudinal Analysis of Antibody Cross-Neutralization Following Zika and Dengue Virus Infection in Asia and the Americas. J Infect Dis . Available from: doi: 10.1093/infdis/jiy164 Premkumar, L., Collins, M., Graham, S., Liou, G. A., Lopez, C. A., Jadi, R., Balmaseda, A., Brackbill, J. A., Dietze, R., Camacho, E., De Silva, A. D., Giuberti, C., Dos Reis, H. L., Singh, T., Heimsath, H., Weiskopf, D., Sette, A., Osorio, J. E., Permar, S. R., Miley, M. J., Lazear, H. M., Harris, E. & de Silva, A. M. (2018) Development of Envelope Protein Antigens To Serologically Differentiate Zika Virus Infection from Dengue Virus Infection. J Clin Microbiol . 56(3). Available from: doi: 10.1128/JCM.01504-17 Page 1 of 3 Journal Publications 1 2 3

Explore Dhammika Gunasekera’s journey from Royal College head prefect to Genetech’s owner and philanthropic force in Sri Lanka. Dhammika Gunasekera Owner of Genetech and Managing Trustee of Genetech Research Institute (GRI) Dhammika Gunasekera is the Owner of Genetech after the demise of his beloved wife Dr. Maya Gunasekera, the Founder of Genetech. He is also the owner of Dienge purveyors of handcrafted silver, fine art, gems and jewellery. Dhammika greatly values generosity and helps a large number of people and institutions financially. For example, he has given donations to the Sri Lanka Cancer Society, sponsored the Devapathiraja College (a school founded by his grandfather Sir Ernest De Silva) Rugby team in Rathgama, a rural area in Sri Lanka and met university tuition fees of students. He was a partner at Messrs. U. N. Gunasekera, a construction firm in Sri Lanka established by his father. The first two five-star hotels in Sri Lanka, namely, Lanka Oberoi (Cinnamon Grand) and Ceylon Inter-Continental (Kingsbury) were built by this company. He graduated from Imperial College London in 1989 with first class honours in civil engineering (BEng). Broadening his horizons to the field of accountancy, he became a passed finalist of the Institute of Chartered Accountants of Sri Lanka in 1986. Furthermore, he topped his batch in the Bachelor of Science degree that he completed at University of Colombo in 1984. He was also the head prefect of Royal College, Colombo in 1980.

Explore career opportunities at Genetech in molecular biology, biotechnology, and more. Join our team of scientists, accountants, receptionists, and other professionals. Job Vacancies Apologies - We are not recruiting for any position at this time. Please check again later. You can follow our Facebook page, Instagram page and LinkedIn page to stay updated on job opportunities, internship opportunities, and the services we offer at Genetech.