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- Journal Publications - Page 2 | Genetech
Sathkumara, H. D., Merritt, A. J., Corea, E. M., Krishnananthasivam, S., Natesan, M., Inglis, T. J. J. & De Silva, A. D. (2018) Clinical, Bacteriologic, and Geographic Stratification of Melioidosis Emerges from the Sri Lankan National Surveillance Program. Am J Trop Med Hyg . 98(2), 607-615. Available from: doi: 10.4269/ajtmh.17-0441 Grifoni, A., Weiskopf, D., Arlehamn, C. S. L., Angelo, M., Leary, S., Sidney, J., Frazier, A., Phillips, E., Mallal, S., Mack, S. J., Tippalagama, R., Goonewardana, S., Premawansa, S., Premawansa, G., Wijewickrama, A., De Silva, A. D. & Sette, A. (2018) Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 714 adults from Colombo, Sri Lanka. Hum Immunol . 79(2), 87-88. Available from: doi: 10.1016/j.humimm.2017.12.007 Patil, V. S., Madrigal, A., Schmiedel, B. J., Clarke, J., O'Rourke, P., de Silva, A. D., Harris, E., Peters, B., Seumois, G., Weiskopf, D., Sette, A. & Vijayanand, P. (2018) Precursors of human CD4+ cytotoxic T lymphocytes identified by single-cell transcriptome analysis. Sci Immunol . 3(19). Available from: doi: 10.1126/sciimmunol.aan8664 Nanayakkara, K. K., Rodrigo, U. G., Perera, K. L. N. & Nanayakkara, C. D. (2017) Pre-natal diagnosis of thalassaemia in Sri Lanka: A ten year review. J Obstet Gynaecol . 37(7), 861-863. Available from: doi: 10.1080/01443615.2017.1306841 de Silva, W.S.I., Perera, M.M.N., Perera, K.L.N.S., Wickramasuriya, & A.M., Jayasekera G.A.U. (2017) In silico Analysis of osr40c1 Promoter Sequence Isolated from Indica Variety Pokkali. Rice Science, Vol. 24 (4): 228-234 Available from: doi: 10.1016/j.rsci.2016.11.002 . Gunasekara, J.M.A., Jayasekera, G.A.U, Perera, K.L.N.S. & Wickramasuriya, A.M, (2017) Development of a Sri Lankan rice variety Bg 94-1 harbouring cry2A gene of Bacillus thuringiensis resistant to rice leaffolder [Cnaphalocrocis medinalis (Guenée)]. Journal of the National Science Foundation of Sri Lanka, 45(2): 143–157. Available from: doi: 10.4038/jnsfsr.v45i2.8180 Goonawardhana, N.D.S., Jayasekara, G.S.K.W., Elanahai, V., Udagama, P.V., & Fernandopulle N.D. (2017) Population genetic data for ten miniSTR loci in the Sri Lankan population. International Journal of Legal Medicine. 131(4):969-970. Available from: doi: 10.1007/s00414-016-1512-3 Tian, Y., Babor, M., Lane, J., Schulten, V., Patil, V. S., Seumois, G., Rosales, S. L., Fu, Z., Picarda, G., Burel, J., Zapardiel-Gonzalo, J., Tennekoon, R. N., De Silva, A. D., Premawansa, S., Premawansa, G., Wijewickrama, A., Greenbaum, J. A., Vijayanand, P., Weiskopf, D., Sette, A. & Peters, B. (2017) Unique phenotypes and clonal expansions of human CD4 effector memory T cells re-expressing CD45RA. Nat Commun. 8(1), 1473. Available from: doi: 10.1038/s41467-017-01728-5 Grifoni, A., Angelo, M. A., Lopez, B., O'Rourke, P. H., Sidney, J., Cerpas, C., Balmaseda, A., Silveira. C. G. T., Maestri, A., Costa, P. R., Durbin, A. P., Diehl, S. A., Phillips, E., Mallal, S., De Silva, A. D., Nchinda, G., Nkenfou, C., Collins, M. H., de Silva, A. M., Lim, M. Q., Macary, P. A., Tatullo, F., Solomon, T., Satchidanandam, V., Desai, A., Ravi, V., Coloma, J., Turtle, L., Rivino, L., Kallas, E. G., Peters, B., Harris, E., Sette, A. & Weiskopf, D. (2017) Global Assessment of Dengue Virus-Specific CD4+ T Cell Responses in Dengue-Endemic Areas. Front Immunol. Available from: doi: 10.3389/fimmu.2017.01309 Grifoni, A., Pham, J., Sidney, J., O'Rourke, P. H., Paul, S., Peters, B., Martini, S. R., de Silva, A. D., Ricciardi, M. J., Magnani, D. M., Silveira, C. G. T., Maestri, A., Costa, P. R., de-Oliveira-Pinto, L. M., de Azeredo, E. L., Damasco, P. V., Phillips, E., Mallal, S., de Silva, A. M., Collins, M., Durbin, A., Diehl, S. A., Cerpas, C., Balmaseda, A., Kuan, G., Coloma, J., Harris, E., Crowe Jr, J. E., Stone, M., Norris, P. J., Busch, M., Vivanco-Cid, H., Cox, J., Graham, B. S., Ledgerwood, J. E., Turtle, L., Solomon, T., Kallas, E. G., Watkins, D. I., Weiskopf, D. & Sette, A. (2017) Prior Dengue virus exposure shapes T cell immunity to Zika virus in humans. J Virol. 91(24). Available from: doi: 10.1128/JVI.01469-17 Uehara, A., Tissera, H. A., Bodinayake, C. K., Amarasinghe, A., Nagahawatte, A., Tillekeratne, L. G., Cui, J., Reller, M. E., Palihawadana, P., Gunasena, S., De Silva, A. D., Wilder-Smith, A., Gubler, D. J., Woods, C. W. & Sessions, O. M. (2017) Analysis of Dengue Serotype 4 in Sri Lanka during the 2012-2013 Dengue Epidemic. Am J Trop Med Hyg. 97(1), 130-136. Available from: doi: 10.4269/ajtmh.16-0540 Krishnananthasivam, S., Jayathilaka, N., Sathkumara, H. D., Corea, E., Natesan, M. & De Silva, A. D. (2017) Host gene expression analysis in Sri Lankan melioidosis patients. PLoSNegl Trop Dis . 11(6). Available from: doi: 10.1371/journal.pntd.0005643 Krishnananthasivam, S., Sathkumara, H. D., Corea, E., Natesan, M. & De Silva, A. D. (2017) Gene Expression Profile of Human Cytokines in Response to Burkholderia pseudomallei Infection. mSphere . 2(2). Available from: doi: 10.1128/mSphere.00121-17 Grifoni, A., Angelo, M., Sidney, J., Paul, S., Peters, B., de Silva, A. D., Phillips, E., Mallal, S., Diehl, S. A., Botten, J., Boyson, J., Kirkpatrick, B. D., Whitehead, S. S., Durbin, A. P., Sette, A. & Weiskopf, D. (2017) Patterns of Cellular Immunity Associated with Experimental Infection with rDEN2Δ30 (Tonga/74) Support Its Suitability as a Human Dengue Virus Challenge Strain. J Virol . 91(8). Available from: doi: 10.1128/JVI.02133-16 Natesan, M., Corea, E., Krishnananthasivam, S., Sathkumara, H. D., Dankmeyer, J. L., Dyas, B. K., Amemiya, K., De Silva, A. D. & Ulrich, R. G. (2017) Calprotectin as a Biomarker for Melioidosis Disease Progression and Management. J Clin Microbiol. 55(4), 1205-1210. Available from: doi: 10.1128/JCM.02284-16 Angelo, M. A., Grifoni, A., O'Rourke, P. H., Sidney, J., Paul, S., Peters, B., De Silva, A. D., Phillips, E., Mallal, S., Diehl, S. A., Kirkpatrick, B. D., Whitehead, S. S., Durbin, A. P., Sette, A. & Weiskopf, D. (2016) Human CD4+ T cell responses to an attenuated tetravalent dengue vaccine parallel those induced by natural infection, in magnitude, HLA restriction and antigen specificity. J Virol . 91(5). Available from: doi: 10.1128/JVI.02147-16 Bodinayake, C. K., Tillekeratne, L. G., Nagahawatte, A., Devasiri, V., Kodikara Arachichi, W., Strouse, J. J., Sessions, O. M., Kurukulasooriya, R., Uehara, A., Howe, S., Ong, X. M., Tan, S., Chow, A., Tummalapalli, P., De Silva, A. D., Østbye, T., Woods, C. W., Gubler, D. J. & Reller, M. E. (2016) Emergence of Epidemic Dengue-1 Virus in the Southern Province of Sri Lanka. PLoS Negl Trop Dis. 10(10). Available from: doi: 10.1371/journal.pntd.0004995 Kamaral, L. C. J., Dassanayaka, P. N., Perera, K. L. N. S. & Perera, S. A. C. N. (2016) SSR markers reveal the population structure of Sri Lankan yellow dwarf coconuts (Cocos nucifera L.). Tree Genetics & Genomes 12, 116. Available from: doi: 10.1007/s11295-016-1076-x Kirupananthan, R., Kamaral, L. C. J., Galhena, G. H., Perera, K. L. N. S. & Magamage, M. P. S. (2016) Address the public health and food security concerns of babesiosis through molecular detection of Babesia bovis in suspected carrier cattle of selected localities in Sri Lanka. Procedia Food Science 6: 213-219. Available from: doi: 10.1016/j.profoo.2016.02.053 Weiskopf, D., Angelo, M. A., Grifoni, A., O'Rourke, P. H., Sidney, J., Paul, S., De Silva, A. D., Phillips, E., Mallal, S., Premawansa, S., Premawansa, G., Wijewickrama, A., Peters, B. & Sette, A. (2016) HLA-DRB1 Alleles Are Associated With Different Magnitudes of Dengue Virus-Specific CD4+ T-Cell Responses. J Infect Dis. 214(7), 1117-1124. Available from: doi: 10.1093/infdis/jiw309 de Alwis, R., Bangs, D. J., Angelo, M. A., Cerpas, C., Fernando, A., Sidney, J., Peters, B., Gresh, L., Balmaseda, A., de Silva, A. D., Harris, E., Sette, A. & Weiskopf, D. (2016) Immunodominant Dengue Virus-Specific CD8+ T Cell Responses Are Associated with a Memory PD-1+ Phenotype. J Virol. 90(9), 4771-4779. Available from: doi: 10.1128/JVI.02892-15 Olsen, A., Chen, Y., Ji, Q., Zhu, G., De Silva, A. D., Vilchèze, C., Weisbrod, T., Li, W., Xu, J., Larsen, M., Zhang, J., Porcelli, S. A., Jacobs Jr, W. R. & Chan, J. (2016) Targeting Mycobacterium tuberculosis Tumor Necrosis Factor Alpha-Downregulating Genes for the Development of Antituberculous Vaccines. MBio. 7(3). Available from: doi: 10.1128/mBio.01023-15 Tissera, H., Amarasinghe, A., Gunasena, S., De Silva, A. D., Yee, L. W., Sessions, O., Muthukuda, C., Palihawadana, P., Lohr, W., Byass, P., Gubler, D. J. & Wilder-Smith, A. (2016) Laboratory-Enhanced Dengue Sentinel Surveillance in Colombo District, Sri Lanka: 2012-2014. PLoS Negl Trop Dis. 10(2). Available from: doi: 10.1371/journal.pntd.0004477 Weiskopf, D., Angelo, M., Zapardiel, J., Seumois, G., De Silva, A., De Silva, A. D., Vijay, P., Peters, B. & Sette, A. (2016) DENV-specific CD4 T-cells dominantly recognize capsid-derived epitopes and display a cytotoxic phenotype. J Immunol . 196 (1). Available from: https://www.jimmunol.org/content/196/1_Supplement/147.13/tab-article-info Padumadasa, C., Perera, K. L. N. & Sankalpani, E. M. N. (2016) DNA intercalation and cleavage studies of plumbagin and phenanthroline-based Cu(II) complex, [Cu(PLN)(PHEN)]NO3. Int J Chem Stud. 4(4), 87-90. Available from: https://www.chemijournal.com/archives/?year=2016&vol=4&issue=4&ArticleId=282&si=false Fernando, A. N., Malavige, G. N., Perera, K. L. N., Premawansa, S., Ogg, G. S. & De Silva, A. D. (2015) Polymorphisms of Transporter Associated with Antigen Presentation, Tumor Necrosis Factor-α and Interleukin-10 and their Implications for Protection and Susceptibility to Severe Forms of Dengue Fever in Patients in Sri Lanka. Journal of Global Infectious Diseases. 7(4): 157–164. Available from: doi: 10.4103/0974-777X.170501 Weiskopf, D., Cerpas, C., Angelo, M. A., Bangs, D. J., Sidney, J., Paul, S., Peters, B., Sanches, F. P., Silvera, C. G., Costa, P. R., Kallas, E. G., Gresh, L., de Silva, A. D., Balmaseda, A., Harris, E. & Sette, A. (2015) The Human CD8+ T-Cell Responses Against the 4 Dengue Virus Serotypes Are Associated With Distinct Patterns of Protein Targets. J Infect Dis . 212(11), 1743-1751. Available from: doi: 10.1093/infdis/jiv289 Page 2 of 3 Journal Publications 1 2 3
- Research Policies | Genetech
GRI Research Policies for External Researchers Genetech offers scientific expertise, technical services and laboratory facilities for research projects. External researchers will have access to all the following services: Bench space and access to all equipment at GRI Scientific and technical expertise of GRI permanent staff Common chemicals and supplies Assistance in ordering and receiving research supplies Library, computer and internet facilities at GRI Short term sample storage at 4 C, -20 C and -80 C. Coordination of international shipment of specimen (subject to local and international export/import regulations) Above services can be obtained under following broad categories, with the flexibility to accommodate the individual researcher's requirements.
- Contact us | Genetech
54 Kitulwatte Road, Colombo 08, Sri Lanka +94 112696992 +94 11 2696881 Fax: +94 (0) 11 2686137 Email: info@genetechsrilanka.com Head of Forensics, Parentage Testing and DNA Typing: Dr. Nandika Perera Email: nandika@genetechsrilanka.com Head of the School of Gene Technology and Disease Diagnostics: Ms. Yoshitha Wahalathanthri Email: yoshitha@genetechsrilanka.com DNA Sequencing Services Email: sequencing.genetech@gmail.com Contact Form Name Email Contact Number Subject Message Success! Message received. Send
- DNA Sequencing | Genetech
DNA Sequencing Genetech is an authorised agent for a world-leading company of genomic analysis which provides a wide variety of services including DNA sequencing and oligo nucleotide synthesis. This has enabled Genetech to provide the following services to Sri Lanka at an affordable price range. DNA Sequencing services Capillary Electrophoresis Sequencing CES analyses DNA sequences using Big Dye chemistry (Sanger Sequencing) and the ABI 3730xl analyser. CES can be performed either in individual PCR tubes or in 96 well plates for high throughput sequencing. The reaction can be conducted using both universal as well as custom made primers. The method is commonly used to sequence relatively shorter fragments of DNA for a variety of purposes. Sequencing of PCR products and plasmid CES is generally used for sequencing of PCR products and plasmid DNA up to 1,000 bp in length. A special CES service is also available for the ‘difficult sequencing’ such as high GC rich DNA, homopolymers, repetitive sequences and those with strong secondary structures. In addition, we accept the unamplified DNA and unprocessed biological samples for sequencing services. We also undertake to sequence PCR products containing nonspecific bands. Upon request, post sequence analysis (sequence alignments, phylogenetic tree construction, genome annotation etc.) services are also available to help the researchers interpret the results. Sequencing bacterial and fungal colonies 16S r-RNA gene sequencing is a common method used to identify bacterial species. As per the customer requirement, we undertake to sequence different length options up to 1400 bp. For the sequencing of fungal colonies, we provide three options: 18S rRNA gene (> 1,600 bp guaranteed), 26S rRNA gene (> 1,300 bp guaranteed) and ITS region (> 500 bp guaranteed). We also offer post-sequencing analysis services to assist species identification. Next-Generation Sequencing NGS, massively parallel or deep sequencing are related terms that describe a DNA sequencing technology which has been developed for genomic research during recent years. The technology performs parallel sequencing of millions of DNA fragments which are assembled into single genome using bioinformatics analysis. In contrast to the first-generation Sanger sequencing technology, NGS provides a much more efficient tool enabling the sequencing of the entire human genome within a single day. We offer numerous NGS sequencing techniques such as Whole Genome Sequencing, Metagenome Sequencing, Exome Sequencing, Transcriptome Sequencing and Epigenome Sequencing. Different NGS platforms are available to meet the varying requirement of these techniques. Our scientists will help you choose the best NGS option and platforms depending on your requirement. We also offer to assist in the bioinformatics analysis of NGS data. Contact us
- Application Process | Genetech
Application Process 01 CV Submission Send us your CV to info@genetechsrilanka.com if you believe your profile matches our requirements for a job advertised on our website. Please make sure you meet the essential requirements before applying for any role. 02 First Interview If we find your CV impressive and your profile meets our requirements after reviewing, we will invite you to an interview with our senior scientists/recruitment team to further assess your skills and get to know you more. The majority of the interview will be strength based, and you can view our top interview tips to help prepare yourself. We are committed to ensuring that our recruitment practices are barrier-free, and as inclusive as possible for everyone. This includes making adjustments for people who require them to perform to the best of their ability. 03 Final Interview If we find your performance at the first interview great and better than most candidates who applied for the same position, we will invite you to the final stage of our recruitment process – an interview with our CEO. 04 Offer Finally, the best candidate(s) will be invited to join our team at Genetech.
- PCR Technology | Genetech
Polymerase Chain Reaction (PCR) Technology (18 hours) This course is suitable for school-level, undergraduate and graduate students, and those engaged in scientific research, diagnostics and teaching which involves Polymerase Chain Reaction (PCR) Technology. Theory: Guidelines for PCR Principle of PCR Critical factors for successful PCR Designing PCR primers Standard practices in a PCR Laboratory Troubleshooting and prevention of carryover contamination Optimization strategies for PCR PCR product analysis: Detection of PCR products by gel electrophoresis Methods of purification and quantification of PCR products Methods of labelling of PCR products (PCR probes) and visualization of label Cloning of PCR products: TOPO cloning DNA sequence analysis of PCR product PCR Applications: Restriction Fragment Length Polymorphism (RFLP) and Randomly Amplified Polymorphic DNA (RAPD) analysis Short Tandem Repeat (STR) (micro-satellite) analysis Multiplex PCR Reverse Transcription (RT)-PCR PCR-ELISA (Enzyme Linked Immunosorbent Assay) In-situ PCR Quality Control/Quality Assurance of PCR assays Practicals: Extraction of DNA from cells, blood stains for PCR A standard PCR assay Analysis of PCR products by agarose and acrylamide gel electrophoresis Strategies for optimization of PCR Purification of PCR products Labelling of PCR products Primer design using online sequence databases PCR-RFLP assay Multiplex PCR assay RT-PCR assay PCR-ELISA assay PCR troubleshooting View FAQs Contact us If you are interested in doing this course at Genetech, please submit the Inquiry Form below or email us at info@genetechsrilanka.com to receive further details. View Inquiry Form
- Samudi Mohotti | Genetech
Samudi Mohotti Senior Scientist Samudi Mohotti commenced her professional career at Genetech as a Scientific Officer at the division of parentage testing in 2004. In subsequent years, she was promoted to the post of Senior Scientist and currently oversees the entire process of parentage testing. She is one of the most experienced scientists in the field of DNA typing and has contributed to submit over 3,000 DNA test reports for civil and criminal cases to the Sri Lankan Judiciary. She took part in the development of an allele frequency databases of autosomal STR markers for Sri Lankans ethnicities and co-authored a journal paper in a high-impact journal, Forensic Science International: Genetics. In addition to DNA typing, she is involved in many research projects conducted by Genetech on contract basis to meet the requests from both state and private institutes. She is also a key member of the team which maintains the ISO 15189 quality management system of our laboratory. Samudi obtained her BSc degree in Biological Sciences from the University of Colombo, Sri Lanka and her Master’s degree in Applied Microbiology from the University of Kelaniya, Sri Lanka.
- Advanced Certificate Course in Molecular Techniques for DNA Fingerprinting | Genetech
Advanced Certificate Course in Molecular Techniques for DNA Fingerprinting For Graduates, Undergraduates, Pre-University and A/L Students Why choose this course? This course provides in-depth coverage of fundamental molecular techniques in gene technology, with a special focus on DNA fingerprinting—the gold standard for individual identification. Students will gain expertise in a broad range of essential molecular biology techniques, preparing them for successful careers in state-of-the-art laboratories worldwide. A certificate will be issued upon completion of the course. Who can register for this course? This course is ideal for undergraduates and graduates in biology, biotechnology, or biomedical science who are seeking to advance their postgraduate studies or enhance their career prospects. It is also highly beneficial for current and recently completed A/L students (Edexcel, Cambridge, and Local A/L) who aim to pursue higher education in these fields. Course Content The course encompasses both theoretical and practical aspects of the following. Basic setup of a molecular biological lab Handling biological samples for DNA fingerprinting Chelex and solid-phase DNA extraction methods DNA quantification Multiplex PCR Commercial kits for DNA profiling Agarose gel electrophoresis Capillary electrophoresis Generating and analysing DNA profiles SNPs for human identification Mitochondrial DNA analysis and X and Y chromosome testing Animal and plant forensics Sex determination and detection of chromosomal anomalies DNA sequence analysis Individual hands-on training will be provided. Duration and fees This course will run from 9.00 am to 4.00 pm on 10 weekdays. The programme fee will be LKR 64,500 which is to be paid before the registration in order to confirm and reserve your place. Places will be offered on a first come first served basis. Email now If you are interested in participating in this training programme, send us an email with your details to info@genetechsrilanka.com View FAQs Contact us View Inquiry Form
- MPhil and MSc Projects | Genetech
Research leading to the award of MPhil Determination of Population Structure of Yellow Dwarf Coconut Population in Sri Lanka Department of Botany. Chandima Kamral, M.Phil., Faculty of Applied Science, University of Sri Jayawardanapura; Coconut Research Institute, Lunuwila, Sri Lanka, 2015 (partially conducted at Genetech). Morphological and molecular identification of Oreochromis niloticus and its hybrids present in selected reservoirs in Sri Lanka. Saroopa Samaradivakara, M.Phil, Faculty of Veterinary Medicine and Animal Sciences, University of Peradeniya, Sri Lanka, 2009. Establishment of DNA based HLA Typing in Sri Lanka for forensic and transplant purposes. Induwara Gooneratne, M.Phil, Department of Forensic Medicine, Faculty of Medicine, University of Peradeniya, Sri Lanka, 2007. MSc Research Projects Detection and confirmed of Brucella abortus in bovine aborted fetuses by PCR in selected localities in Sri Lanka. Samudi N. K. Mohotti, M.Sc., Department of Microbiology, Faculty of Science, University of Kelaniya, Sri Lanka, 2017. Genetic characterization and molecular phylogeny of Aedes aegypti (Diptera: Culicidae) in Sri Lanka based on COI gene. H.A.K.M. Dharmarathne, M.Sc., IBMBB, University of Colombo, Sri Lanka, 2016. HLA Typing of MHC Class I Molecules by PCR & Sequencing in Sri Lanka. Rashmi Tippalagama, M.Sc., IBMBB, University of Colombo, Sri Lanka, 2012. Molecular epidemiology of Dengue virus. Barathy Logendra, M.Sc. in Experimental Biotechnology, Postgraduate Institute of Science University of Peradeniya, Sri Lanka 2010. Molecular Characterization of Chikungunya Virus isolates in Sri Lanka. Ishara Herath, M.Sc in Experimental Biotechnology, Postgraduate Institute of Science University of Peradeniya, Sri Lanka 2010. Molecular Characterization of human Cytomegalovirus in a cohort of immunocompromised patients in Sri Lanka. Imalka M. W. Gunasekera, M.Sc in Experimental Biotechnology, Postgraduate Institute of Science University of Peradeniya, Sri Lanka 2010. Suitability of using SSR markers to differentiate tissue cultured and other Musa varieties. Fintan. S. Gonsal, M.Sc. Postgraduate Institute of Agriculture, University of Peradeniya, Sri Lanka, 2009. Molecular characterization of Mycobacterium tuberculosis isolates in Sri Lanka utilizing the mycobacterium interspersed repetitive units (MIRU) typing method. Nandika Perera, M.Sc. Molecular Life Sciences, Institute of Biochemistry Molecular Biology and Biotechnology, University of Colombo, Sri Lanka, 2009. Development of a single step reverse transcriptase-polymerase chain reaction assay to detect chikungunya virus in clinical samples. Navodhi Wickremasinghe, M.Sc. in Experimental Biotechnology, Postgraduate Institute of Science University of Peradeniya, Sri Lanka 2009. Determination of sensitivity of multiplex and duplex PCR in the determination of Marek's disease virus. Shamini Akushla Wickramage, M.Sc in Experimental Biotechnology, Postgraduate Institute of Science University of Peradeniya, Sri Lanka 2009. Establishment of a Molecular Diagnostic System for Detecting Human Papillomavirus in Clinical Samples. Rubatharshini Ambikaibakan, M.Sc. in Experimental Biotechnology, Postgraduate Institute of Science University of Peradeniya, Sri Lanka 2008. Development of a low cost multiplex PCR-based diagnostic assay for Down Syndrome. A. Mary Renuka Fernando, M.Sc. in Experimental Biotechnology, Postgraduate Institute of Science University of Peradeniya, Sri Lanka 2008. Determination of the sensitivity of PCR based non-radiolabeled hybridization for the detection of Mycobacterium tuberculosis. K.A.D. Ravi Vishwajith, M.Sc. in Experimental Biotechnology, Postgraduate Institute of Science University of Peradeniya, Sri Lanka 2006. Establishment of a molecular diagnostic system for detecting Y-chromosomal microdeletions which cause male infertility. Thiruchelvam Kariharan, M.Sc. in Experimental Biotechnology, Postgraduate Institute of Science University of Peradeniya, Sri Lanka 2006.
- Molecular Diagnostics | Genetech
Molecular Diagnostics Did you know? We pioneered the use of molecular diagnostics in Sri Lanka. This field, which was almost unknown to the medical fraternity in Sri Lanka is now widely used in delivering high quality patient management. Molecular diagnostics is now an accepted and even essential part of the health care system since it was introduced to Sri Lanka by us in 2002. How we strengthened our clients' trust In order to standardise our tests and strengthen our clients' trust, We have applied for and obtained ISO 15189 accreditation. Thus, our tests including those related to molecular disease diagnostics are excellent in all aspects. The importance of nucleic acids Infectious diseases are caused by a wide variety of organisms, ranging from multi-cellular parasites and fungi to uni-cellular bacteria to non-cellular viruses. These organisms cover a wide range of phyla, and have extremely diverse ways of infecting human beings. In spite of these differences, they all possess nucleic acids (DNA or RNA molecules), their hereditary material. This DNA or RNA forms the basis of their individuality, and because it is the basis of diversity, it is possible to identify these organisms from their DNA or RNA. What we offer with PCR technology Unlike other diagnostic methods, which rely on microscopy, culture, biochemical characteristics and indirect antibody detection, molecular diagnostics seeks evidence of a disease at the very basic causative level by detecting the nucleic acids based on PCR (Polymerase Chain Reaction) technology. This technology is also used to detect changes or mutations in our DNA, which can cause disease conditions known as genetic disorders. While some of these genetic disorders are passed from generation to generation, some happen spontaneously. Genetech offers DNA-based testing services for a wide variety of such genetic disorders and cancer markers. Contact us View Price List and Sample Collection Guide